Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease

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Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease

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作者：Zubeyde Bayram-Weston ; ^{Bayram-WestonZ@cardiff.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Elliott Olsen ; David J. Harrison ; Stephen B. Dunnett ; Simon P. Brooks
关键词：Golgi&ndash ; Cox method ; Paraformaldehyde ; Section thickness ; Huntington's disease ; zQ175 mice
刊名：Journal of Neuroscience Methods
出版年：2016
出版时间：30 May 2016
年：2016
卷：265
期：Complete
页码：81-88
全文大小：1222 K

文摘

class="label">•: id="par0005">A modified reliable Golgi–Cox method is described.
class="label">•: id="par0010">It is inexpensive and can be performed in any neuroscience lab.
class="label">•: id="par0015">Perfusion–fixation with 4% paraformaldehyde yields good results.
class="label">•: id="par0020">Pre-sectioning of perfusion-fixed brain tissue is neither required nor preferred for modified Golgi–Cox staining.
class="label">•: id="par0025">We demonstrate reliable changes in striatal dendritic morphology in the Q175 mouse model of Huntington's disease.

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