Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

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• 作者：Maria E. Gonzalez¹ ; ² ; Emily E. Martin¹ ; ² ; Talha Anwar¹ ; ² ; Caroline Arellano-Garcia¹ ; ² ; Natasha Medhora¹ ; ² ; Arjun Lama¹ ; ² ; Yu-Chih Chen² ; ³ ; Kevin S. Tanager¹ ; ² ; Euisik Yoon³ ; ⁴ ; Kelley M. Kidwell⁵ ; Chunxi Ge⁶ ; Renny T. Franceschi⁶ ; Celina G. Kleer¹ ; ² ; ⁷ ; ^{kleer@umich.edu}
• 关键词：mesenchymal stem cell ; tumor stroma ; breast cancer ; metastasis ; DDR2 ; discoidin domain receptor ; collagen ; microenvironment ; phosphorylated DDR2 ; EZH2
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：31 January 2017
• 年：2017
• 卷：18
• 期：5
• 页码：1215-1228
• 全文大小：4610 K
• 卷排序：18

文摘

MSCs are present in human breast cancer metastatic microenvironment DDR2 regulates MSC phenotype, collagen deposition function, and migration DDR2 activation in breast cancer depends on stroma-derived DDR2 Inhibition of DDR2 in the tumor microenvironment reduces metastasis