Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study

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• 作者：S.B. Pai ; R.B. Pai ; R.M. Lalitha ; S.V. Kumaraswamy ; N. Lalitha ; R.N. Johnston ; M.K. Bhargava
• 关键词：oral cancer ; carcinoembryonic antigen ; squamous cell carcinoma
• 刊名：International Journal of Oral and Maxillofacial Surgery
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：35
• 期：8
• 页码：746-749
• 全文大小：230 K

文摘

Expression of the oncofoetal glycoprotein, carcinoembryonic antigen (CEA), has been observed in a number of malignancies and is also being pursued as a target for anti-cancer therapy. This study explored the status of this biochemical entity in the oral squamous cell carcinoma (SCC) in South India caused by extensive chewing habits. Squamous cell carcinoma in the study belonged to grade I and grade II. Tumour staging of the patients recruited in the study ranged from T2N1M0 to T4N3M0. Of the grade II cases studied, 88 % (7 out of 8) showed expression of CEA. The 2 cases of grade I SCC of buccal mucosa also showed positive anti-CEA staining. If the results from this pilot study can be validated with a larger sample size, a role can be attributed to this tumour marker in oral neoplasia, thereby opening up avenues for using CEA as an additional diagnostic marker in oral SCC in this population and as a possible target for anti-cancer therapy.