Globoidnan A: a lignan from Eucalyptus globoidea inhibits HIV integrase

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• 作者：Ovenden ; Simon P.B. ; Yu ; Jin ; San Wan ; Soo ; Sberna ; Gian ; Murray Tait ; R. ; Rhodes ; David ; Cox ; Susan ; et. al.
• 关键词：Phenylpropanoid ; Cyclolignan ; Lignan ; Globoidnan A ; Eucalyptus globoidea ; HIV-integrase ; 3-(3 ; 4-dihydroxyphenyl) lactic acid ; 4-(3 ; 4-Dihydroxyphenyl)-6 ; 7-dihydroxy-2-naphthalene carboxylic acid
• 刊名：Phytochemistry
• 出版年：2004
• 出版时间：December, 2004
• 年：2004
• 卷：65
• 期：24
• 页码：3255-3259
• 全文大小：267 K

文摘

An HTS campaign aimed at the identification of inhibitors of HIV integrase showed that the methanol extract from the buds of a Eucalyptus globoidea was active. Bioassay guided fractionation of this extract resulted in the purification and structural elucidation of the lignan, globoidnan A (<b>1b>) as the only compound in the extract responsible for the inhibition of HIV integrase. The compound was found to inhibit the combined 3aaa processing and strand transfer activity of HIV integrase with an ICb>50