Copper-catalyzed oxidative cyclization of chalcone and benzylic amine leading to 2,5-diaryl oxazoles via carbon-carbon double bond cleavage

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• 作者：Dongfang Liu ; Jintao Yu ; Jiang Cheng
• 关键词：Copper-catalyzed ; Cyclization ; Oxazoles benzylic amine
• 刊名：Tetrahedron
• 出版年：11 February, 2014
• 年：2014
• 卷：70
• 期：6
• 页码：1149-1153
• 全文大小：1501 K

文摘

A copper-catalyzed oxidative cyclization of chalcone with benzylic amine is achieved, providing 2,5-diaryl oxazoles in moderate to good yields. The procedure employs O₂ as a clean oxidant and involves an oxidative cleavage of the CC bond as the key step.