The role of interleukin-21 in HIV infection

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• 作者：Suresh Pallikkuth ; Anita Parmigiani ; Savita Pahwa
• 关键词：IL-21 and T cells ; IL-21 and B cells ; HIV and IL-21 ; Immunomodulation by IL-21 ; IL-21 and immunity
• 刊名：Cytokine and Growth Factor Reviews
• 出版年：2012
• 出版时间：August-October, 2012
• 年：2012
• 卷：23
• 期：4-5
• 页码：173-180
• 全文大小：393 K

文摘

Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common ¦Ã chain (¦Ã_c). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.