Liraglutide restores angiogenesis in palmitate-impaired human endothelial cells through PI3K/Akt-Foxo1-GTPCH1 pathway

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• 作者：Jing Ke¹ ; Rui Wei¹ ; Fei Yu ; Jingjing Zhang ; Tianpei Hong ; ^{tpho66@bjmu.edu.cn}
• 关键词：DAHP ; 2 ; 4-diamino-6-hydroxypyrimidine ; DPP-4 ; dipeptidyl peptidase 4 ; eNOS ; endothelial nitric oxide synthase ; Foxo1 ; forkhead box O1 ; GLP-1 ; glucagon-like peptide-1 ; GTPCH1 ; guanosine 5&prime ; -triphosphate cyclohydrolase 1 ; HUVECs ; human umbilical vein endothelial cells ; L-NAME ; N-nitro-l-arginine-methyl ester ; NO ; nitric oxide ; NOS ; nitric oxide synthase ; PA ; palmitic acid ; TFP ; trifluoperazine dihydrochloride
• 刊名：Peptides
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：86
• 期：Complete
• 页码：95-101
• 全文大小：2230 K
• 卷排序：86

文摘

Liraglutide restores endothelial tube formation impaired by palmitate in HUVECs. Liraglutide upregulates GTPCH1 and eNOS levels, thus promoting angiogenesis. The liraglutide-mediated regulation of GTPCH1 and eNOS requires Foxo1 inactivation. The effect of liraglutide on angiogenesis is mediated via PI3K/Akt-Foxo1 pathway.