Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts

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Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts

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作者：Dachuan Dong^a ; Liangyuan Li^a ; Pengyu Gu^b ; Tao Jin^a ; Mingda Wen^a ; Caihua Yuan^a ; Xiang Gao^b ; Chang Liu^a ; Zhao Zhang^a ; ^{zhangzhao@njnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：ACADM ; acyl‐coenzyme A dehydrogenase ; middle chain (C4&ndash ; C12) ; ACADS ; acyl‐coenzyme A dehydrogenase ; short chain (C4&ndash ; C8) ; ACADVL ; acyl‐coenzyme A dehydrogenase ; very long chain ; ACSL1 ; acyl‐CoA synthetase long‐chain family member 1 ; ANP ; atrial natriuretic peptide ; BNP ; brain natriuretic peptide ; CD36 ; fatty acid translocase ; CPT ; carnitine palmitoyltransferase ; CS ; citrate synthase ; EF ; ejection fraction ; FABP ; fatty acid binding protein ; FS ; fractional shortening ; GLUT ; solute carrie
刊名：FEBS Letters
出版年：2015
出版时间：30 November 2015
年：2015
卷：589
期：23
页码：3631-3639
全文大小：3242 K

文摘

•: We sketched the timing and directionality of “substrate-switching” in two HF models.
•: Cardiac-specific PP2Acα ablation developed cardiac hypertrophy.
•: The mRNA expression of HK2, PKM2 and GLUT1/GLUT4 ratio could be used as an indicator to access the HF state.
•: Metabolic remodeling is a complicated procedure that is orchestrated under multi-level control.

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