Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

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• 作者：Yiwen Jiang¹ ; ⁵ ; ⁶ ; Voichita Dana Marinescu¹ ; ⁵ ; ⁷ ; Yuan Xie¹ ; Malin Jarvius² ; Naga Prathyusha Maturi¹ ; Caroline Haglund² ; Sara Olofsson¹ ; Nanna Lindberg¹ ; Tommie Olofsson³ ; Caroline Leijonmarck⁴ ; Gö ; ran Hesselager⁴ ; Irina Alafuzoff¹ ; Må ; rten Fryknä ; s² ; Rolf Larsson² ; Sven Nelander¹ ; ^{sven.nelander@igp.uu.se} ; Lene Uhrbom¹ ; ⁸ ; ^{lene.uhrbom@igp.uu.se}
• 关键词：glioblastoma ; glioma ; cancer stem cell ; cell of origin ; neural stem cell ; oligodendrocyte precursor cell ; self-renewal ; mouse model ; drug response ; central nervous system
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：24 January 2017
• 年：2017
• 卷：18
• 期：4
• 页码：977-990
• 全文大小：5712 K
• 卷排序：18

文摘

The cell of origin affects mouse glioblastoma development and phenotype A neural stem-cell-like origin produces higher malignancy and drug sensitivity The mouse cell origin signature separates distinct phenotypes of human glioblastoma The mouse cell origin signature predicts glioblastoma cell response to temozolomide