Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function

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Tropisetron attenuated the anxiogenic effects of social isolation by modulating nitrergic system and mitochondrial function

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作者：Shayan Amiri^a ; ^b ; Hossein Amini-Khoei^a ; ^b ; Arya Haj-Mirzaian^a ; ^b ; Maryam Rahimi-Balaei^c ; Parvaneh Naserzadeh^d ; AhmadReza Dehpour^a ; ^b ; Shahram Ejtemaei Mehr^a ; ^b ; ^{ejtemam@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{ejtemam@tums.ac.ir" class="auth_mail" title="E-mail the corresponding author} ; Mir-Jamal Hosseini^e ; ^f ; ^{jamal_hossini@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：SIS ; social isolation stress ; O&NS ; oxidative and nitrosative stress ; AG ; aminoguanidine ; HBT ; hole-board test ; OFT ; open-field test ; EPM ; elevated plus maze
刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
出版年：2015
出版时间：December 2015
年：2015
卷：1850
期：12
页码：2464-2475
全文大小：1270 K

文摘

•: Early SIS induced anxiety-like behaviors in the adult socially isolated mice.
•: Early SIS induced mitochondrial dysfunction and oxidative stress in hippocampus.
•: Aminoguanidine and L-NAME reversed the anxiogenic effects of early SIS.
•: Tropisetron alleviated SIS-induced anxiety and mitochondrial function.
•: Tropisetron improved mitochondrial function and behavior by regulating iNOS.

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