An apolar Pistacia lentiscus L. leaf extract: GC-MS metabolic profiling and evaluation of cytotoxicity and apoptosis inducing effects on SH-SY5Y and SK-N-BE(2)C cell lines

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An apolar Pistacia lentiscus L. leaf extract: GC-MS metabolic profiling and evaluation of cytotoxicity and apoptosis inducing effects on SH-SY5Y and SK-N-BE(2)C cell lines

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作者：Simona Piccolella^a ; Paola Nocera^a ; Petronia Carillo^a ; Pasqualina Woodrow^a ; Vincenza Greco^a ; Lorenzo Manti^b ; Antonio Fiorentino^a ; Severina Pacifico^a ; ^{severina.pacifico@unina2.it" class="auth_mail" title="E-mail the corresponding author}
关键词：Pistacia lentiscus L. ; GC-MS ; Pentacyclic triterpenes ; Cytotoxicity ; Apoptosis-inducing effects ; Pro-oxidant activity
刊名：Food and Chemical Toxicology
出版年：2016
出版时间：September 2016
年：2016
卷：95
期：Complete
页码：64-74
全文大小：924 K

文摘

•: An apolar Pistacia lentiscus leaf extract (Pl-C) was prepared.
•: Pl-C was rich in pentacyclic triterpenes and α-tocopherol.
•: Pl-C inhibited dose-dependently SH-SY5Y cell viability.
•: Pl-C (100 μg/mL) activated caspase-3 and induced disturbance in cell redox balance.
•: Apoptotic DNA fragments were detected in Pl-C (100 μg/mL)-treated SH-SY5Y cells.