T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA

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T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA

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作者：Durwood B. Ray^a ; ^b ; ^{raydb@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Gerald A. Merrill^a ; ¹ ; ^{Merrilljer@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Frederic J. Brenner^a ; ^{BrennerFJ@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Laurie S. Lytle^a ; ^{LSLytle@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Tan Lam^b ; ² ; ^{tanmlam@aol.com" class="auth_mail" title="E-mail the corresponding author} ; Aaron McElhinney^a ; ³ ; ^{aaron.mcelhinney@msn.com" class="auth_mail" title="E-mail the corresponding author} ; Joel Anders^a ; ⁴ ; ^{jba6776@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Tara Tauber Rock^a ; ⁵ ; ^{taramtauber@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Jennifer Kier Lyker^a ; ⁶ ; ^{jenlyker@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Scott Barcus^a ; ⁷ ; ^{scott.barcus@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kara Hust Leslie^a ; ⁸ ; ^{karaleslie31@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jill M. Kramer^a ; ⁹ ; ^{jkramer@buffalo.edu" class="auth_mail" title="E-mail the corresponding author} ; Eric M. Rubenstein^a ; ¹⁰ ; ^{emrubenstein@bsu.edu" class="auth_mail" title="E-mail the corresponding author} ; Karen Pryor Schanz^a ; ¹¹ ; ^{kkschanz@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Amy J. Parkhurst^a ; ¹² ; ^{amyjparkhurst@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Michelle Peck^a ; ¹³ ; ^{Peckmichellea@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kimberly Good^a ; ¹⁴ ; ^{kimberlyross@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kristi Lemke Granath^a ; ¹⁵ ; ^{granathkl@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Nicole Cifra^a ; ¹⁶ ; ^{cifranm1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Jessalee Wantz Detweiler^a ; ¹⁷ ; ^{mattnjessd@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Laura Stevens^a ; ¹⁸ ; ^{laura.stevens2011@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Richard Albertson^a ; ¹⁹ ; ^{rma165@psu.edu" class="auth_mail" title="E-mail the corresponding author} ; Rachael Deir^a ; ²⁰ ; ^{rd41193n@pace.edu" class="auth_mail" title="E-mail the corresponding author} ; Elisabeth Stewart^a ; ²¹ ; ^{elisabeth.e.stewart@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Katherine Wingard^a ; ²² ; ^{wingardkl1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Micah Rose Richardson^a ; ^{RichardsonMR1@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Sarah B. Blizard^a ; ^{BlizardSB1@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Lauren E. Gillespie^a ; ^{GillespieLE1@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Charles E. Kriley^a ; ^{cekrieley@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; Daniel I. Rzewnicki^a ; ^{Rzewnickidi1@gcc.edu" class="auth_mail" title="E-mail the corresponding author} ; David H. Jones^a ; ^b ; ²³ ; ^{j.jeandave@gmail.com" class="auth_mail" title="E-mail the corresponding author}
关键词：NIH/3T3 ; HRAS ; Tansformed ; GhrasT-NIH/3T3 ; In vitro/in vivo tumorigenic progression ; Metastasis ; Punctuated evolution ; Chromoplexy ; Chromothripsis ; Doubling time method
刊名：Experimental Cell Research
出版年：2016
出版时间：1 January 2016
年：2016
卷：340
期：1
页码：1-11
全文大小：1624 K

文摘

•: A tumor progression model derived from a new T24 HRAS transformed NIH/3T3 cell line.
•: T1-A, T2-A, T3-HA, T4PA lines derived from GhrasT-NIH/3T3, T1-A, T2-A, T3-HA tumors.
•: PCR detected the human HRAS oncogene in T2-A and T4-PA metastatic tumors.
•: These five new cell lines showed a progressive increase in tumorigenic potential.
•: New method obtained doubling times using daily photomicrographs of gridded plates.