Evolutionary characteristics of morbilliviruses during serial passages in vitro: Gradual attenuation of virus virulence

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Evolutionary characteristics of morbilliviruses during serial passages in vitro: Gradual attenuation of virus virulence

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作者：Fuxiao Liu ; Xiaodong Wu ; Lin Li ; Yanli Zou ; Shan Liu ; Zhiliang Wang ; ^{wangzhiliang@cahec.cn" class="auth_mail" title="E-mail the corresponding author}
关键词：Morbilliviruses ; Virulence attenuation ; Serial passages ; Quasispecies ; Fitness ; Mutation
刊名：Comparative Immunology, Microbiology and Infectious Diseases
出版年：2016
出版时间：August 2016
年：2016
卷：47
期：Complete
页码：7-18
全文大小：8102 K

文摘

•: Overviewing the development of live-attenuated vaccine strains against morbilliviruses by consecutive passages in vitro.
•: Reviewing the mechanism concerning a relationship between virulence attenuation and viral evolution in morbilliviruses.

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