Anti-inflammatory effect of a fatty acid mixture with high ω-9:ω-6 ratio and low ω-6:ω-3 ratio on rats submitted to dental extraction

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• 作者：Radamé ; s Bezerra Melo^a ; Paulo Goberlâ ; nio de Barros Silva^b ; ^{paulo_goberlanio@yahoo.com.br} ; ^{paulo.goberlanio@gmail.com} ; Reinaldo Barreto Oriá ; ^c ; José ; Ulisses de Souza Melo^d ; Conceiç ; ã ; o da Silva Martins^c ; Aline Matos Cunha^a ; Paulo Roberto Leitã ; o Vasconcelos^a
• 关键词：EPA ; eicosapentaenoic acid ; DHA ; docosahexaenoic acid ; ω-3 ; omega-3 ; ω-6 ; omega-6 ; G1 ; sham control group ; G2 ; negative control group ; G3 ; positive control group ; G4 ; treatment group ; POD3 ; third postoperative day ; MPO ; myeloperoxidase ; CTAB ; cetrimonium bromide ; TNF-α ; tumore necrosis factor alpha ; IL-1β ; interleukin 1 beta ; EDTA ; ethylenediamine tetraacetic acid ; ECL ; electrogenerated chemiluminescence ; COX ; cyclooxygenase ; LOX ; lipoxygenase ; AA ; arachidonic acid ; PG ; prostaglandin ; LT ; leucot
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：74
• 期：Complete
• 页码：63-68
• 全文大小：1699 K
• 卷排序：74

文摘

The fatty acid mixture tested in this study (high ω-9:ω-6 ratio and low ω-6:ω-3 ratio) effectively reduced TNF-α levels post tooth extraction in rats. The fatty acid mixture tested in this study (high ω-9:ω-6 ratio and low ω-6:ω-3 ratio) effectively reduced myeloperoxidase levels post tooth extraction in rats. Clinically the fatty acid mixture tested in this study (high ω-9:ω-6 ratio and low ω-6:ω-3 ratio) effectively reduced masseter edema post tooth extraction in rats. Histologically the fatty acid mixture tested in this study (high ω-9:ω-6 ratio and low ω-6:ω-3 ratio) effectively reduced osteoclast numbers at the site of dental extraction in rats.