Endoglin is required in Pax3-derived cells for embryonic blood vessel formation

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Endoglin is required in Pax3-derived cells for embryonic blood vessel formation

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作者：K Young^a ; ^b ; ^c ; LT Krebs^a ; E Tweedie^a ; B Conley^a ; M Mancini^a ; ^d ; HM Arthur^e ; L Liaw^a ; ^b ; T Gridley^a ; ^b ; CPH Vary^a ; ^b ; ^{varyc@mmc.org" class="auth_mail" title="E-mail the corresponding author}
关键词：HHT ; Endoglin ; Pax3 ; Intersomitic ; Vascular malformation ; Dorsal aorta ; Intersomitic
刊名：Developmental Biology
出版年：2016
出版时间：1 January 2016
年：2016
卷：409
期：1
页码：95-105
全文大小：3279 K

文摘

•: First embryonic development study using conditional endoglin targeting.
•: Embryonic lethal phenotype with conditional deletion of endoglin in Pax3-positive cells.
•: Loss of endoglin causes disorganization of aortic vascular smooth cell investment..
•: Pax3Cre-driven deletion of endoglin causes intersomitic vessel malformation and leakiness.
•: Loss of endoglin in Pax3-positive cells alters expression of smooth muscle differentiation genes.

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