Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis

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Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis

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作者：Maria Razzoli¹ ; ⁸ ; Andrea Frontini² ; ⁸ ; Allison Gurney¹ ; ⁸ ; Eleonora Mondini² ; Cankut Cubuk³ ; Liora S. Katz⁴ ; Cheryl Cero¹ ; Patrick J. Bolan⁵ ; Joaquin Dopazo³ ; Antonio Vidal-Puig⁶ ; ⁷ ; Saverio Cinti² ; Alessandro Bartolomucci¹ ; ^{abartolo@umn.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：Subordinate ; Energy expenditure ; UCP1 ; P2RX5 ; Purinergic
刊名：Molecular Metabolism
出版年：2016
出版时间：January 2016
年：2016
卷：5
期：1
页码：19-33
全文大小：6182 K

文摘

•: Adaptive thermogenesis/BAT functions determine the vulnerability to stress-induced obesity.
•: βARs are dispensable for stress and cold-induced BAT browning.
•: A sympathetic/brown adipocyte purinergic pathway is identified in mice and humans.
•: ATP increases UCP1 expression in brown adipocytes.

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