A new Leishmania-specific hypothetical protein, LiHyT, used as a vaccine antigen against visceral leishmaniasis

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A new Leishmania-specific hypothetical protein, LiHyT, used as a vaccine antigen against visceral leishmaniasis

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作者：Ví ; vian Tamietti Martins^a ; Daniela Pagliara Lage^b ; Mariana Costa Duarte^c ; Lourena Emanuele Costa^b ; Esther Garde^d ; Marcella Rezende Rodrigues^c ; Miguel Angel Chá ; vez-Fumagalli^b ; Daniel Menezes-Souza^c ; Bruno Mendes Roatt^c ; Carlos Alberto Pereira Tavares^a ; Manuel Soto^d ; Eduardo Antonio Ferraz Coelho^b ; ^{eduardoferrazcoelho@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author}
关键词：Hypothetical proteins ; Leishmania infantum ; Vaccine ; Immunoproteomic approach ; Immune adjuvants ; Th1 immune response
刊名：Acta Tropica
出版年：2016
出版时间：February 2016
年：2016
卷：154
期：Complete
页码：73-81
全文大小：1617 K

文摘

•: Immunoproteomic approach performed in Leishmania infantum.
•: Selection from a Leishmania-specific hypothetical protein.
•: Evaluation of its immunogenicity in BALB/c mice.
•: Protective efficacy against L. infantum infection.
•: A new candidate to compose an effective vaccine against visceral leishmaniasis.

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