A new multiplex method for the diagnosis of peroxisomal disorders allowing simultaneous determination of plasma very-long-chain fatty acids, phytanic, pristanic, docosahexaenoic and bile acids by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry

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A new multiplex method for the diagnosis of peroxisomal disorders allowing simultaneous determination of plasma very-long-chain fatty acids, phytanic, pristanic, docosahexaenoic and bile acids by high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry

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作者：Michela Semeraro^a ; ¹ ; ^{michela.semeraro@opbg.net" class="auth_mail" title="E-mail the corresponding author} ; Cristiano Rizzo^a ; ¹ ; Sara Boenzi^a ; Marco Cappa^b ; Enrico Bertini^c ; Giacomo Antonetti^a ; Carlo Dionisi-Vici^a
关键词：PDs ; peroxisomal disorders ; LC-MS/MS ; liquid chromatography-tandem mass spectrometry ; CV ; coefficient of variation ; VLCFAs ; very-long-chain fatty acids ; Pri ; pristanic acid ; PUFAs ; polyunsaturated fatty acids ; DHA ; docosahexaenoic acid ; Phy ; phytanic acid ; PBDs ; peroxisomal biogenesis disorders ; GC&ndash ; MS ; gas chromatography&ndash ; mass spectrometry ; ESI-MS/MS ; electrospray ionization tandem mass spectrometry ; UPLC ; ultra-performance liquid chromatography ; DAABD-AE ; 4-[2-(N ; N-dimethylamino) eth
刊名：Clinica Chimica Acta
出版年：2016
出版时间：1 July 2016
年：2016
卷：458
期：Complete
页码：159-164
全文大小：619 K

文摘

•: Quantification of VLCFA, DHA, phytanic, pristanic and bile acids by LC-APCI-MS/MS
•: Simple and rapid sample preparation without the step of derivatization
•: All metabolites are well separated in a single chromatographic run.
•: The method allows the diagnosis of most peroxisomal disorders.