Simultaneous quantitation of hexacosanoyl lysophosphatidylcholine, amino acids, acylcarnitines, and succinylacetone during FIA-ESI-MS/MS analysis of dried blood spot extracts for newborn screening
Newborn screening analyzes biomarkers in DBS to detect metabolic disorders.
•
C26:0-LPC is a biomarker for X-ALD and other peroxisomal biogenesis disorders.
•
A method was developed that added C26:0-LPC to dried blood spot analysis.
•
The method uses a single punch, extraction, and analysis by FIA–ESI–MS/MS.
•
C26:0-LPC, amino acids, acylcarnitines, and SUAC are simultaneously quantitated.
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.