Simultaneous quantitation of hexacosanoyl lysophosphatidylcholine, amino acids, acylcarnitines, and succinylacetone during FIA-ESI-MS/MS analysis of dried blood spot extracts for newborn screening
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文摘

Newborn screening analyzes biomarkers in DBS to detect metabolic disorders.

C26:0-LPC is a biomarker for X-ALD and other peroxisomal biogenesis disorders.

A method was developed that added C26:0-LPC to dried blood spot analysis.

The method uses a single punch, extraction, and analysis by FIA–ESI–MS/MS.

C26:0-LPC, amino acids, acylcarnitines, and SUAC are simultaneously quantitated.

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