Cryptosporioptide: A bioactive polyketide produced by an endophytic fungus Cryptosporiopsis sp.

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• 作者：Muhammad Saleem ; Muhammad Imran Tousif ; Naheed Riaz ; Ishtiaq Ahmed ; Barbara Schulz ; Muhammad Ashraf ; Rumana Nasar ; Gennaro Pescitelli ; Hidayat Hussain ; Abdul Jabbar ; Nusrat Shafiq ; Karsten Krohn
• 关键词：Endophytic fungus ; Cryptosporiopsis sp. ; Novel polyketide ; Lipoxygenase inhibition ; Anti-Bacillus megaterium ; TDDFT CD calculations
• 刊名：Phytochemistry
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：93
• 期：Complete
• 页码：199-202
• 全文大小：423 K

文摘

An antibiotic polyketide, Cryptosporioptide (1) was isolated from the culture extract of the endophytic fungus Cryptosporiopsis sp. The structure of Cryptosporioptide has been established with the help of 1D (¹H, ¹³C), 2D NMR (HSQC, HMBC, COSY, NOESY) techniques and mass spectrometry (FABMS, HRFABMS). The absolute configuration was established by means of electronic circular dichroism (ECD). Cryptosporioptide exhibited both lipoxygenase inhibitory and anti-Bacillus megaterium activities.