Opposing Activities of Aurora B Kinase and B56-PP2A Phosphatase on MKlp2 Determine Abscission Timing

详细信息    查看全文

• 作者：Suet Yin Sarah Fung¹ ; ² ; Mayumi Kitagawa¹ ; ² ; Pei-Ju Liao¹ ; Jasmine Wong¹ ; Sang Hyun Lee¹ ; ³ ; ^{sanghyun.lee@duke-nus.edu.sg}
• 关键词：abscission ; Aurora B ; MKlp2 ; PP2A ; ESCRT ; plasma membrane
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：78-86
• 全文大小：3384 K
• 卷排序：27

文摘

The lipid-binding function of MKlp2 promotes abscission by establishing the ICB Aurora B inhibits abscission by phosphoregulation of MKlp2 B56-PP2A opposes Aurora B phosphoregulation of MKlp2 and promotes abscission MKlp2 integrates the opposing Aurora B and B56-PP2A activities for abscission