Solution structure of α-phosphoglucomutase from Leishmania major at 3.5 Å resolution.

Four molecules in asymmetric unit; A-D and B-C of identical inter-subunit geometry.

Enzyme monomeric in solution - constituted of four domains.

Conformational variability of domain IV approximated by normal mode analyses.

30">Enzymatic parameters were determined; prospects for inhibitor design were explored.