Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

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Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

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作者：Deepika Awasthi^a ; Sheela Nagarkoti^a ; Amit Kumar^a ; Megha Dubey^a ; Abhishek Kumar Singh^a ; Priya Pathak^a ; Tulika Chandra^b ; Manoj Kumar Barthwal^a ; Madhu Dikshit^a ; ^{madhu_dikshit@cdri.res.in" class="auth_mail" title="E-mail the corresponding author} ; ^{madhudikshit@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：4-HNE ; 4-hydroxynonenal ; ABAH ; 4-aminobenzoic acid hydrazide ; ApoB ; Aproprotein B 100 ; BSA ; bovine serum albumin ; CD ; cluster of differentiation ; DAPI ; 4ʹ ; 6-diamidino-2-phenylindole ; DCF-DA ; 2 ; 7-dichlorofluorescein diacetate ; DFP ; diisopropyl fluorophosphates ; DHE ; dihydroethidium ; DPI ; diphenyleneiodonium chloride ; HDL ; high density lipoprotein ; IRAKs ; interleukin-1 receptor associated kinase ; IL-1β ; interleukin-1 beta ; IL-8 ; Interleukin 8 ; LDL ; low density lipoprotein ; LPC ; lysophosphatidylcho
刊名：Free Radical Biology and Medicine
出版年：2016
出版时间：April 2016
年：2016
卷：93
期：Complete
页码：190-203
全文大小：3729 K

文摘

•: OxLDL mediated the release of neutrophil extracellular traps (NETs) from human PMNs.
•: OxLDL induced ROS generation and NETs formation was dependent on NADPH oxidase.
•: TLR-PKC-IRAK-MAPK pathway was found to be involved in oxLDL induced NETs formation.
•: Oxidized phospholipids component of oxLDL was crucial and most potent NETs inducer.

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