Critical role for cytosolic group IVA phospholipase A<sub>2</sub> in early adipocyte differentiation and obesity

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Critical role for cytosolic group IVA phospholipase A₂ in early adipocyte differentiation and obesity

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作者：Lucí ; a Peñ ; a^a ; ^b ; Clara Meana^a ; ^b ; Alma M. Astudillo^a ; ^b ; Gema Lordé ; n^a ; ^b ; Martí ; n Valdearcos^a ; ^b ; Hiroyasu Sato^c ; Makoto Murakami^c ; ^d ; Jesú ; s Balsinde^a ; ^b ; Marí ; a A. Balboa^a ; ^b ; ^{mbalboa@ibgm.uva.es" class="auth_mail" title="E-mail the corresponding author}
关键词：ADM ; adipogenic differentiation medium ; AA ; arachidonic acid ; cPLA2α ; cytosolic group IVA phospholipase A2α ; MCE ; mitotic clonal expansion ; ASCs ; adipose stem cell ; MEFs ; mouse embryonic fibroblast ; HFD ; high fat diet ; MTT ; 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium-bromide
刊名：Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids
出版年：2016
出版时间：September 2016
年：2016
卷：1861
期：9
页码：1083-1095
全文大小：2551 K

文摘

•: Cytosolic group IVA PLA₂α is a key enzyme in arachidonic acid mobilization.
•: Reduced cytosolic group IVA PLA₂α levels decrease adipocyte differentiation in vitro and in vivo.
•: Pretreatment of preadipocytes with arachidonic acid increases adipogenesis.
•: Cytosolic Group IV PLA₂α has a key role in adipogenesis.

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