The olfactory bulbectomized rat as a model of depression: The hippocampal pathway

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The olfactory bulbectomized rat as a model of depression: The hippocampal pathway

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作者：J.C. Morales-Medina^a ; ^{jmoralesm@cinvestav.mx" class="auth_mail" title="E-mail the corresponding author} ; ^{jcmm.cinvestav@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; T. Iannitti^b ; ^{tommaso.iannitti@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; A. Freeman^c ; ^{afreem16@kent.edu" class="auth_mail" title="E-mail the corresponding author} ; H.K. Caldwell^c ; ^d ; ^{hcaldwel@kent.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：AChE ; acetylcholinesterase ; BDNF ; brain derived neurotrophic factor ; CaMKII ; calmodulin-dependent protein kinase II ; DG ; dentate gyrus ; DHEA ; dehydroepiandrosterone ; EC ; entorhinal cortex ; FST ; forced swim test ; GSK-3β ; glycogen synthase kinase 3β ; LTP ; long-term potentiation ; MWM ; Morris water maze ; NMDA ; N-Methyl-d-aspartate ; NORT ; novel object recognition test ; NPY ; neuropeptide Y ; p-CREB ; cAMP response element-binding protein phosphorylation ; p-ERK1 ; extra-cellular signal-regulated kinase 1
刊名：Behavioural Brain Research
出版年：2017
出版时间：15 January 2017
年：2017
卷：317
期：Complete
页码：562-575
全文大小：2135 K

文摘

•: Olfactory bulbectomy is a model of major cellular dysfunction in the hippocampus.
•: Olfactory bulbectomy (OBX) induces behavioral deficits similar to clinical depression.
•: Imipramine and curcumin reduce hippocampal neuroinflammation in OBX rats.
•: Citalopram and ZSET1446 improve dentate gyrus neurogenesis in OBX rats.
•: Nefiracetam, sunifiram and rivastigmine restore LTP in CA1 hippocampus in OBX rats.

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