Histological and proteomic profile of diabetic versus non-diabetic dilated cardiomyopathy

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Histological and proteomic profile of diabetic versus non-diabetic dilated cardiomyopathy

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作者：Andrea Frustaci^a ; ^b ; ; Fabiola Ciccosanti^b ; Cristina Chimenti^a ; ^b ; Roberta Nardacci^b ; Marco Corazzari^b ; ^c ; Romina Verardo^b ; Giuseppe Ippolito^b ; Nicola Petrosillo^b ; Gian Maria Fimia^b ; ^d ; ¹ ; Mauro Piacentini^b ; ^c ; ¹
关键词：PTS ; Patients ; DM ; Diabetes mellitus ; DbCM ; Diabetic Cardiomyopathy ; ROS ; Reactive oxygen species ; RAGE ; Advanced glycation end-products ; IDCM ; Idiopathic dilated cardiomyopathy ; LV ; Left ventricular ; 2D-DIGE ; Two-dimensional difference gel electrophoresis ; rMnSOD ; Human manganese superoxide dismutase
刊名：International Journal of Cardiology
出版年：2016
出版时间：15 January 2016
年：2016
卷：203
期：Complete
页码：282-289
全文大小：1621 K

文摘

•: Diabetic cardiomyopathy (DbCM) is indistinguishable from idiopathic dilated cardiomyopathy (IDCM).
•: Definition of pathophysiology and markers of DbCM is highly desirable.
•: Morphology, proteomics and reactive oxygen species (ROS) production are evaluated in DbCM vs IDCM.
•: DbCM is a ROS-mediated damage of myocyte's structural proteins and DNA

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