Efficient bioreductive production of (S)-N-Boc-3-hydroxypiperidine using ketoreductase ChKRED03
详细信息    查看全文
文摘
•

Bioreduction of NBPO afforded the chiral intermediate of ibrutinib, (S)-NBHP.

•

The reaction was catalyzed with ChKRED03 with excellent stereoselectivity.

•

Using 3 g/L crude enzyme, 200 g/L substrate was completely reduced in 3 h.

NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via email.