Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease

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作者：Richard Gordon¹ ; Neeraj Singh ; Vivek Lawana ; Anamitra Ghosh ; Dilshan S. Harischandra ; Huajun Jin ; Colleen Hogan ; Souvarish Sarkar ; Dharmin Rokad ; Nikhil Panicker ; Vellareddy Anantharam ; Anumantha G. Kanthasamy ; Arthi Kanthasamy ; ^{arthik@iastate.edu" class="auth_mail" title="E-mail the corresponding author}
关键词：DCFH-DA ; 2&prime ; 7&prime ; -dichlorodi-hydrofluorescein diacetate ; FBS ; fetal bovine serum ; KO ; knockout ; TH ; tyrosine hydroxylase ; PKCδ ; protein kinase Cδ ; PD ; Parkinson's disease ; PHOX ; NADPH oxidase ; WT ; wild-type
刊名：Neurobiology of Disease
出版年：2016
出版时间：September 2016
年：2016
卷：93
期：Complete
页码：96-114
全文大小：3233 K

文摘

•: Proinflammatory stressors including misfolded α-syn upregulates PKCδ in microglia.
•: PKCδ translocates to nucleus and promotes proinflammatory responses in microglia.
•: PKCδ mediates inflammagen-activated NFκB signaling pathway in activated microglia.
•: PKCδ knockout mice exhibit dampened neuroinflammatory responses induced by LPS.
•: PKCδ deletion protects against neuroinflammation and dopaminergic neurodegeneration.