Sirtuins in metabolism, stemness and differentiation

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• 作者：Marcelo Correia^a ; ^b ; ^c ; ¹ ; ² ; Tâ ; nia Perestrelo^a ; ^b ; ^c ; ^d ; ¹ ; Ana S. Rodrigues^a ; ^c ; Marcelo F. Ribeiro^a ; ^e ; Sandro L. Pereira^a ; ^c ; Maria I. Sousa^a ; ^e ; Joã ; o Ramalho-Santos^a ; ^e ; ^{jramalho@uc.pt}
• 关键词：Stem cells ; Pluripotency ; Differentiation ; Metabolism ; Sirtuins ; SIRT1
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3444-3455
• 全文大小：862 K
• 卷排序：1861

文摘

Sirtuins are master regulators of a broad range of cellular processes. Sirtuins are metabolic and energetic cellular sensors. The involvement of sirtuins in regulating pluripotency, differentiation and reprogramming are summarized. SIRT1 plays a crucial role in pluripotent stem cells under oxidative stress conditions.