Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth

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• 作者：Elisa M. Vuorinen^a ; ^b ; ¹ ; ^{elisa.vuorinen@uta.fi} ; Nina K. Rajala^a ; ^b ; ¹ ; ^{nina.rajala@uta.fi} ; Hanna E. Rauhala^a ; ^{hanna.e.rauhala@uta.fi} ; Anssi T. Nurminen^a ; ^b ; ^{anssi.nurminen@uta.fi} ; Vesa P. Hytö ; nen^a ; ^b ; ^{vesa.hytonen@uta.fi} ; Anne Kallioniemi^a ; ^b ; ^{anne.kallioniemi@uta.fi}
• 关键词：KPNA7 ; Importin alpha 8 ; Nuclear transfer ; Affinity chromatography ; Pancreatic cancer
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：211-219
• 全文大小：767 K
• 卷排序：1863

文摘

First study identifying KPNA7 cargo proteins in pancreatic cancer cells Altogether 377 proteins, most with a predicted nuclear localization, were found. KPNA7 binding and nuclear transfer was validated for two proteins, MVP and ZNF414. MVP and ZNF414 have a key role in the regulation of pancreatic cancer cell growth. The role and importance of nuclear transfer in cancer pathogenesis is reinforced.