The cAMP pathway and the control of adrenocortical development and growth

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• 作者：Cyrille de Joussineau^a ; Isabelle Sahut-Barnola^a ; Isaac Levy^b ; Emmanouil Saloustros^b ; Pierre Val^a ; Constantine A. Stratakis^b ; Antoine Martinez^a ; ^{antoine.martinez@univ-bpclermont.fr}
• 关键词：cAMP ; PKA ; Adrenal ; Pathology
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2012
• 出版时间：31 March 2012
• 年：2012
• 卷：351
• 期：1
• 页码：28-36
• 全文大小：1004 K

文摘

In the last 10 years, extensive studies showed that the cAMP pathway is deregulated in patients suffering from adrenocortical tumours, and particularly in primary pigmented nodular adrenocortical disease (PPNAD). Here we describe how evidence arising from the analysis of patients?data, mouse models and in vitro experiments, have shed light on the cAMP pathway as a central player in adrenal physiopathology. We also show how novel data generated from mouse models may point to new targets for potential therapies.