Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells

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• 作者：Ruchi Ghildiyal ; Ellora Sen ; ^{ellora@nbrc.ac.in}
• 关键词：IFNγ ; interferon gamma ; RIG-I ; retinoic acid (RA)-inducible gene-I ; SFM ; serum free media ; ChIP ; chromatin immunoprecipitation ; NFκB ; nuclear factor kappa B ; PGC-1α ; peroxisome proliferator-activated receptor gamma coactivator-1 alpha ; PRMT-1 ; protein arginine methyltransferase 1 ; MTS ; 3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ; TUNEL ; terminal deoxynucleotidyl transferase dUTP nick end labeling
• 刊名：Cytokine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：89
• 期：Complete
• 页码：185-193
• 全文大小：1658 K
• 卷排序：89

文摘

Sp-1 and NFκB serves as negative regulator of RIG-I in IFNγ treated glioma cells. IFNγ decreases occupancy of Sp1 and NFκB on RIG-1 promoter. RIG-I inhibition increases expression of de-differentiation markers. IFNγ induced PGC-1α regulates RIG-I expression. Histone methyltransferases G9a and PRMT-1 effect RIG-I and PGC-1α expression oppositely.