An efficient three-component protocol for the synthesis of novel spiro-oxazinobarbiturates

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• 作者：Mohammad Bagher Teimouri ; Tayyebeh Abbasi ; Saloomeh Ahmadian ; Mohammad Reza Poor Heravi ; Reihaneh Bazhrang
• 关键词：Activated acetylenes ; Alloxan ; Azines ; Multicomponent reactions ; Spiro compounds
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：26 September 2009
• 年：2009
• 卷：65
• 期：39
• 页码：8120-8124
• 全文大小：589 K

文摘

Some novel spiro-oxazinobarbiturate derivatives have been successfully synthesized in a one-pot, three-component cascade reaction from various azines (pyridine, isoquinoline, quinoline and phenanthridine), 1,3-dimethylalloxan, and several activated acetylenes (alkyl propiolates, dialkyl acetylenedicarboxylates, and butyne-2-one). The high bond forming efficiency (formation of new C–N, C–C, and C–O bonds) of this reaction makes it attractive for the synthesis of spiro-oxazinobarbiturates in a single operation.