Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum

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• 作者：Wen-Tao Yang¹ ; Gui-Lian Yang¹ ; Qian Wang ; Hai-Bin Huang ; Yan-Long Jiang ; Chun-Wei Shi ; Jian-Zhong Wang ; Ke-Yan Huang ; Yu-Bei Jin ; Chun-Feng Wang ; ^{wangchunfeng@jlau.edu.cn}
• 关键词：Lactobacillus plantarum ; Influenza virus ; M2e ; Neonatal Fc receptor
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：138
• 期：Complete
• 页码：9-21
• 全文大小：3687 K
• 卷排序：138

文摘

Activation of CD80 and CD86 molecules on DCs by NC8-pSIP409-3M2e-Fc. IFN-γ+ producing CD8+ T cells in the MLN were induced by the NC8-pSIP409-3M2e-Fc in mice. Total IgA and IgA+B220+ cells in PP and MLN cells were significantly induced by the NC8-pSIP409-3M2e-Fc in mice. Specific sIgA and activated B cell in the growth center of PP were induced by the NC8-pSIP409-3M2e-Fc in mice. NC8-pSIP409-3M2e-Fc provided 60% and 70% protection against the A/Puerto Rico/8/34(H1N1) and mH9N2 AIV, respectively.