MiR-212-3p inhibits LPS-induced inflammatory response through targeting HMGB1 in murine macrophages

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• 作者：Weiwei Chen^a ; Xiaoying Ma^a ; Peng Zhang^a ; Qifeng Li^b ; ^{lqf989@163.com} ; Xin Liang^a ; ^{xin.liang@ecust.edu.cn} ; Jianwen Liu^a ; ^{liujian@ecust.edu.cn}
• 关键词：LPS ; lipopolysaccharide ; TLRs ; Toll-like receptors ; HMGB1 ; high mobility group box 1 ; miRNAs ; microRNAs ; mRNAs ; messenger RNAs ; siRNA ; small interfering RNA ; UTR ; untranslated region ; Mut ; mutated ; TNF-α ; tumor necrosis factor-alpha ; IL-6 ; interleukin-6 ; ERK ; extracellular regulated protein kinases ; JNK ; c-Jun N-terminal kinase ; MAPKs ; mitogen-activated protein kinases ; NF-κB ; nuclear factor kappa B ; DMEM ; Dulbecco's modified eagle's medium ; qRT-PCR ; quantitative reverse transcription-polymeras
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：350
• 期：2
• 页码：318-326
• 全文大小：1264 K
• 卷排序：350

文摘

miR-212-3p was a novel miRNA found aberrantly expressed in LPS-induced RAW264.7 cells. HMGB1 was revealed to be a totally new target of miR-212-3p in LPS-stimulated inflammatory response. p38 MAPK and ERK signaling pathways can be inhibited by miR-212-3p through targeting HMGB1.