Host factor PRPF31 is involved in cccDNA production in HBV-replicating cells

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• 作者：Wataru Kinoshita^a ; ¹ ; ^{wataru.kinoshita@jt.com} ; Naoki Ogura^a ; ¹ ; ^{naoki.ogura@jt.com} ; Koichi Watashi^b ; ^{kwatashi@nih.go.jp} ; Takaji Wakita^b ; ^{wakita@nih.go.jp}
• 关键词：HBV ; cccDNA ; PRPF31
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：638-644
• 全文大小：849 K
• 卷排序：482

文摘

We identified PRPF31 as a cellular factor involved in HBV cccDNA formation. PRPF31 is recruited to cccDNA. PRPF31 interacts with HBx in the nucleus. PRPF31 and HBx co-overexpression significantly enhanced cccDNA formation.