New fluorinated 1,3-vinylogous amidines as versatile intermediates: synthesis of fluorinated pyrimidin-2(1H)-ones

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• 作者：Santos Fustero ; Julio Piera ; Juan F. Sanz-Cervera ; Raquel Romá ; n ; Benjamin H. Brodsky ; Marí ; a Sá ; nchez-Roselló ; José ; Luis Aceñ ; a and Carmen Ramí ; rez de Arellano
• 关键词：Fluorinated compounds ; 1 ; 3-Vinylogous amidines ; Pyrimidin-2(1H)-ones ; Imines ; Fluorinated nitriles
• 刊名：Tetrahedron
• 出版年：2006
• 出版时间：13 February 2006
• 年：2006
• 卷：62
• 期：7
• 页码：1444-1451
• 全文大小：173 K

文摘

The condensation of the azaenolates derived from readily available ketimines with fluorinated nitriles offers an efficient and straightforward entry to new fluorinated 1,3-vinylogous amidines. These versatile compounds, in turn, react with triphosgene to yield new fluorinated pyrimidin-2(1H)-ones in high yields.