文摘
Lysophosphatidic Acid Acyltransferase ¦Â (LPAAT¦Â) may be critically involved in osteosarcoma cell proliferation. However, the comprehensive mechanisms responsible for regulation of LPAAT¦Â in osteosarcoma cells remain unclear. This study found that enhanced LPAAT¦Â expression was correlated with osteosarcoma cell proliferation. MiR-24, targeted to LPAAT¦Â, was down-regulated in osteosarcoma cells. Overexpression of miR-24 down-regulated LPAAT¦Â expression in osteosarcoma cells. Specifically, overexpression of miR-24 inhibited osteosarcoma cell proliferation, however, such effect was blocked when LPAAT¦Â activity was inhibited. In conclusion, our study indicates that miR-24 is reduced in osteosarcoma cells, contributing to up-regulation of LPAAT¦Â and resultant osteosarcoma cell proliferation.
