Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers

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Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers

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作者：Irina V. Pronina^a ; ¹ ; Vitaly I. Loginov^a ; ¹ ; Alexey M. Burdennyy^a ; Marina V. Fridman^a ; Tatiana P. Kazubskaya^b ; Alexey A. Dmitriev^c ; Eleonora A. Braga^a ; ^{eleonora10_45@mail.ru" class="auth_mail" title="E-mail the corresponding author}
关键词：miRNA ; microRNA ; mRNA ; messenger RNA ; BC ; breast cancer ; OC ; ovarian cancer ; RT-PCR ; reverse transcription PCR ; qPCR ; quantitative PCR ; rs ; Spearman's correlation coefficient ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; FDR ; false discovery rate ; MSP ; methylation specific PCR ; ld ; low differentiated ; md ; moderately differentiated ; hd ; high differentiated ; GO ; Gene Ontology
刊名：Gene
出版年：2016
出版时间：15 January 2016
年：2016
卷：576
期：1
页码：483-491
全文大小：871 K

文摘

•: The hypermethylation of SEMA3B and MIR-129-2 genes was revealed in BC and/or OC.
•: SEMA3B and MIR-129-2 hypermethylation correlated with their down-regulation in BC.
•: RASSF1(A), GPX1 level correlated with miR-129-2 precursor level and methylation in BC.
•: RASSF1(A) and mature miR-129-2 expression levels correlated negatively in BC.
•: Cross-talk of DNA methylation and microRNA impacts on gene expression revealed in BC.