“Tasting‿the cerebrospinal fluid: Another function of the choroid plexus?

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“Tasting‿the cerebrospinal fluid: Another function of the choroid plexus?

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作者：J. Tomá ; s ; C.R.A. Santos ; T. Quintela ; I. Gonç ; alves ; ^{igoncalves@fcsaude.ubi.pt" class="auth_mail" title="E-mail the corresponding author}
关键词：CNS ; central nervous system ; CP ; choroid plexus ; CPEC ; CP epithelial cells ; DMEM ; Dulbecco&rsquo ; s modified Eagle medium ; FBS ; fetal bovine serum ; GPCRs ; G protein-coupled receptors ; ICC ; immunocytochemistry ; IF ; immunofluorescence ; IHC ; immunohistochemistry ; IP3 ; inositol 1 ; 4 ; 5-trisphosphate ; PBS ; phosphate-buffered saline ; Plcβ2 ; phospholipase C-beta 2 ; PROP ; 6-propyl-3-thiouracil ; PTC ; N-phenylthiourea ; RT ; room temperature ; T1R1 ; taste receptors type 1 ; T2R2 ; taste receptors type 2 ; TBS ; Tri
刊名：Neuroscience
出版年：2016
出版时间：21 April 2016
年：2016
卷：320
期：Complete
页码：160-171
全文大小：3984 K

文摘

•: Proteins encoding the taste transduction machinery are present in rat choroid plexus.
•: Rat choroid plexus epithelial cells respond to the bitter compound d-Salicin.
•: Probenecid inhibits choroid plexus epithelial cells response to d-Salicin.
•: The bitter transduction signalling pathway is functional in the choroid plexus.

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