Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1

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• 作者：Ionica Masgras¹ ; Francesco Ciscato¹ ; Anna Maria Brunati² ; Elena Tibaldi² ; Stefano Indraccolo³ ; Matteo Curtarello³ ; Federica Chiara⁴ ; Giuseppe Cannino¹ ; Elena Papaleo⁵ ; Matteo Lambrughi⁵ ; Giulia Guzzo¹ ; Alberto Gambalunga⁴ ; Marco Pizzi⁶ ; Vincenza Guzzardo⁶ ; Massimo Rugge⁶ ; Stefania Edith Vuljan⁴ ; Fiorella Calabrese⁴ ; Paolo Bernardi¹ ; Andrea Rasola¹ ; ⁷ ; ^{andrea.rasola@unipd.it}
• 关键词：Ras/ERK signaling ; TRAP1 ; succinate dehydrogenase ; neurofibromin ; tumor metabolism ; mitochondria ; chaperones ; bioenergetics
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：659-672
• 全文大小：5230 K
• 卷排序：18

文摘

Cells lacking neurofibromin exhibit decreased respiration ERK1/2 inhibits respiratory complex II (SDH) via phosphorylation of the chaperone TRAP1 SDH inhibition by ERK1/2 phosphorylation of TRAP1 is mandatory for neoplastic growth