Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

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Incretin-like effects of small molecule trace amine-associated receptor 1 agonists

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作者：Susanne Raab¹ ; Haiyan Wang¹ ; Sabine Uhles¹ ; Nadine Cole¹ ; Ruben Alvarez-Sanchez¹ ; Basil Kü ; nnecke¹ ; Christoph Ullmer¹ ; Hugues Matile¹ ; Marc Bedoucha¹ ; Roger D. Norcross¹ ; Nickki Ottaway-Parker² ; Diego Perez-Tilve² ; Karin Conde Knape¹ ; ⁴ ; Matthias H. Tschö ; p³ ; Marius C. Hoener¹ ; Sabine Sewing¹ ; ^{sabine.sewing@roche.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Pancreatic β-cell ; Insulin secretion ; Type 2 diabetes ; Incretin hormones ; Obesity
刊名：Molecular Metabolism
出版年：2016
出版时间：January 2016
年：2016
卷：5
期：1
页码：47-56
全文大小：1636 K

文摘

•: TAAR1 is a novel key player in metabolic control.
•: TAAR1 is expressed in β-cells and intestinal enteroendocrine cells in mice and humans.
•: TAAR1 agonist improved glucose tolerance and reduced body weight in mouse disease models.

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