Understanding the impact of 5-HTTLPR, antidepressants, and acute tryptophan depletion on brain activation during facial emotion processing: A review of the imaging literature

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• 作者：Kyeon Raab^a ; ^b ; ^{Kyeon.Raab@med.uni-marburg.de} ; ^{Kyeon.Raab@gmail.com} ; Peter Kirsch^a ; ^{Peter.Kirsch@zi-mannheim.de} ; Daniela Mier^a ; ^{Daniela.Mier@zi-mannheim.de}
• 关键词：5-HTTLPR ; Acute tryptophan depletion ; Amygdala ; Anterior cingulate cortex ; Candidate gene ; Corticolimbic ; Emotion ; Emotion recognition ; Face processing ; Imaging genetics ; Medial prefrontal cortex ; Orbitofrontal cortex ; Serotonin ; Serotonin receptor ; Serotonin transporter ; Social cognition ; SSRI
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：71
• 期：Complete
• 页码：176-197
• 全文大小：1736 K
• 卷排序：71

文摘

We review imaging genetics studies on 5-HTTLPR, serotonin-reuptake inhibiting antidepressant and acute tryptophan depletion effects on facial emotion processing. Imaging genetics studies suggest 5-HTTLPR having an allelic effect on corticolimbic signaling during facial emotion processing. We compare these imaging genetics findings with results from pharmacologic challenge neuroimaging studies on facial emotion processing. Imaging genetics and challenge studies do not reveal a homogeneous pattern. Differences between imaging genetics and challenge studies have to be related to specific serotonergic receptor variations.