Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

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Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation

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作者：Mariana Rinaldi^a ; Laura Thomas^a ; Patricia Mathieu^a ; Pablo Carabias^a ; Maria F. Troncoso^a ; Juana M. Pasquini^a ; Gabriel A. Rabinovich^b ; ^c ; Laura A. Pasquini^a ; ^{laupasq@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
关键词：Galectin-1 ; Demyelination-remyelination ; Microglia ; Lysolecithin ; Phagocytosis
刊名：Neurobiology of Disease
出版年：2016
出版时间：December 2016
年：2016
卷：96
期：Complete
页码：127-143
全文大小：5400 K

文摘

•: Gal-1 treatment after LPC demyelination circumvented damage and enhanced remyelination.
•: Gal-1 shifted microglia from an M1 to an M2 phenotype.
•: Gal-1 increased myelin phagocytosis and improved oligodendroglial differentiation.
•: Gal-1 is a potential therapeutic tool against demyelinating diseases.

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