Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

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Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

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作者：Nicholas A. Gherardin¹ ; ² ; ³ ; ¹⁰ ; Andrew N. Keller⁴ ; ⁵ ; ¹⁰ ; Rachel E. Woolley⁴ ; ⁵ ; Jé ; rô ; me Le Nours⁴ ; ⁵ ; David S. Ritchie² ; ⁶ ; Paul J. Neeson² ; Richard W. Birkinshaw⁴ ; ⁵ ; Sidonia B.G. Eckle¹ ; John N. Waddington¹ ; ³ ; Ligong Liu⁷ ; ⁸ ; David P. Fairlie⁷ ; ⁸ ; Adam P. Uldrich¹ ; ³ ; Daniel G. Pellicci¹ ; ³ ; James McCluskey¹ ; Dale I. Godfrey¹ ; ³ ; ¹¹ ; ^{godfrey@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author} ; Jamie Rossjohn⁴ ; ⁵ ; ⁹ ; ¹¹ ; ^{jamie.rossjohn@monash.edu" class="auth_mail" title="E-mail the corresponding author}
刊名：Immunity
出版年：2016
出版时间：19 January 2016
年：2016
卷：44
期：1
页码：32-45
全文大小：5830 K

文摘

•: Identification of TRAV1-2⁻ MR1 restricted T cells
•: Characterization of autoreactive and folate-derivative-reactive MAIT cells
•: Folate-derivative responsiveness and autoreactivity mediated by CDR3β hypervariability
•: Structure determination of a TRAV1-2⁻ TCR-MR1-antigen complex

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