Endometrial polyps affect uterine receptivity

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• 作者：Beth W. Rackow ; Elisa Jorgensen ; Hugh S. Taylor
• 关键词：Endometrial polyps ; endometrial receptivity ; HOX genes ; infertility
• 刊名：Fertility and Sterility
• 出版年：2011
• 出版时间：30 June 2011
• 年：2011
• 卷：95
• 期：8
• 页码：2690-2692
• 全文大小：97 K

文摘

This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair implantation. These findings suggest a molecular mechanism to support the clinical findings of diminished pregnancy rates in women with endometrial polyps.