Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia

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• 作者：Ross ; Randal G. ; Olincy ; Ann ; Harris ; Josette G. ; Radant ; Allen ; Adler ; Lawrence E. ; Freedman ; Robert
• 关键词：Eye movements ; schizophrenia ; smooth pursuit ; saccades ; family studies ; endophenotype
• 刊名：Biological Psychiatry
• 出版年：1998
• 出版时间：October 15, 1998
• 年：1998
• 卷：44
• 期：8
• 页码：690-697
• 全文大小：72.1 K

文摘

Background: Smooth pursuit eye movement (SPEM) abnormalities are a putative marker of genetic risk for schizophrenia. Accurate SPEM performance requires the subject to activate neural systems responsible for smooth pursuit tracking, while simultaneously suppressing activity of neurons responsible for saccadic movements that would move the eye ahead of the target. This study examined whether specific aspects of SPEM dysfunction cosegregate with genetic risk in parents of schizophrenic probands.