Diagnostic Utility of Acoustic Structure Quantification for Evaluation of Radiation Sialadenitis after Radioactive Iodine Therapy

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• 作者：Sun Hye Jeong ; Hyun Sook Hong ; ^{hshong@schmc.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Eun Hye Lee
• 关键词：Ultrasonography ; Acoustic structure quantification ; Salivary gland ; Thyroid cancer ; Radioactive iodine ; Sialadenitis
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：42
• 期：11
• 页码：2553-2561
• 全文大小：1264 K

文摘

Acoustic structure quantification (ASQ) software was used to analyze statistical information on acquired echo signals, to determine the ability of ASQ to distinguish normal salivary glands of asymptomatic patients from glands of patients with radiation sialadenitis (RS) after radioactive iodine therapy. The ASQ values of 192 salivary glands were compared by multinomial logistic regression analysis, and receiver operating characteristic curves were constructed. Between-observer agreement was assessed by calculating the intra-class correlation coefficient. The mean ASQ values of patients with chronic RS or asymptomatic patients who had undergone radioactive iodine therapy were greater than those of patients with normal glands (p < 0.001). The ratio was associated with the highest odds ratio in patients with chronic RS compared with normal patients. Diagnostic performance was moderate; the intra-class correlation coefficient between observers was very good. ASQ can objectively differentiate RS-affected tissue from normal salivary tissue and is thus valuable for clinically diagnosing RS after radioactive iodine therapy.