A PPAR gamma agonist protects against oral mucositis induced by irradiation in a murine model

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• 作者：Monica Mangoni^a ; ¹ ; Mariangela Sottili^a ; ¹ ; ^{mariangela.sottili@unifi.it} ; Chiara Gerini^a ; Isacco Desideri^a ; Cinzia Bastida^b ; Stefania Pallotta^b ; Francesca Castiglione^c ; Pierluigi Bonomo^a ; Icro Meattini^a ; Daniela Greto^a ; Emanuela Olmetto^a ; Francesca Terziani^a ; Carlotta Becherini^a ; Camilla Delli Paoli^a ; Laura Trombetta^a ; Mauro Loi^a ; Giampaolo Biti^a ; Lorenzo Livi^a
• 关键词：Rosiglitazone ; PPAR gamma agonists ; Radiation-induced toxicity ; Oral mucositis ; Radioprotection
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：64
• 期：Complete
• 页码：52-58
• 全文大小：1712 K
• 卷排序：64

文摘

Oral mucositis is a complication of radiotherapy used for head-neck cancer treatment. Rosiglitazone protects normal tissues from radiation-induced oral mucositis. Rosiglitazone does not protect the tumor from therapeutic effect of irradiation. Rosiglitazone could be proposed as radioprotective agent in head-neck cancer.