JAK2 contributes to the intrinsic capacity of primary hematopoietic cells to respond to stem cell factor

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• 作者：Radosevic ; Nina ; Winterstein ; Dolores ; Keller ; Jonathan R. ; Neubauer ; Hans ; Pfeffer ; Klaus ; et. al.
• 刊名：Experimental Hematology
• 出版年：2004
• 出版时间：February, 2004
• 年：2004
• 卷：32
• 期：2
• 页码：149-156
• 全文大小：220 K

文摘

Stem cell factor (SCF) is the ligand for the receptor tyrosine kinase (RTK) Kit. The literature contains conflicting reports regarding the capacity of SCF to activate JAK2. Previous work has addressed this controversial issue using biochemical approaches. Here we use a genetic approach to determine the direct role of JAK2 in SCF-mediated growth and differentiation of primary hematopoietic cells.